1. Familial Mediterranean feve
1. Familial Mediterranean fever is an autosomal recessivecondition, with high carrier frequencies known for multipleethnicities: Armenian 1 in 8 Ashkenazi Jewish 1 in 13 SephardicJewish 1 in 14 Turkish 1 in 8 What are the chances of an Armenianman and a Sephardic Jewish woman having a baby who is affected withthis condition?
Answer:
This is a simple question which can be directly solved byHardy-Weinberg Equation, which states p2 + q2 + 2pq = 1
The methodology to solve the problem is as follows :
Now, we find the Probability of 2 carriers having an affectedbaby :
Now finally, the Risk of Child being affected can be calculatedas :
Probability = (Carrier status of man) x (Carrier status ofwoman) x (Probability of 2 carriers having an affected baby)
= 0.4570 x 0.3916 x 0.25
= 0.04474
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