947.Ethanol metabolism in the
947.Ethanol metabolism in the liver results in the increase ofthe NADH/NAD+ ratio in the liver cytosol.
946.In gluconeogenesis, the regulatory enzyme fructose1,6-bisphosphatase is inhibited by AMP.
945.Glucose-6-P dehydrogenase deficiency can lead todrug-induced hemolytic anemia because not enough NADH isgenerated.
944.Glucagon and epinephrine are similar in that both promoteglycogenolysis.
943.Phosphofructokinase activity can be decreased by AMP.
942.Protein phosphatase can reverse the action of the kinase onenzymes.
Answer:
947.Ethanol metabolism in the liver results in the increase ofthe NADH/NAD+ ratio in the liver cytosol.-true
Explanation- Consumption and metabolism of ethanol causes highlevels of NADH in the cytosol and mitochondria of the liver cell.Alcohol is oxidized in the cytosol of hepatocytes by alcoholdehydrogenase (ADH), which generates NADH and increases cytosolicNADH/NAD+ ratio.
946.In gluconeogenesis, the regulatory enzyme fructose1,6-bisphosphatase is inhibited by AMP.- true
Explanation- Fructose-1, 6-bisphosphate is an essentialregulatory enzyme in gluconeogenesis and has long beenconsidered as a drug target towards type II diabete. AMP is anallosteric inhibitor that binds to FBPase with positivecoopertivity, and Fru-2,6-P2 is an active site inhibitor which isup-regulated by hormone.
945.Glucose-6-P dehydrogenase deficiency can lead todrug-induced hemolytic anemia because not enough NADH isgenerated.- true
Explanation- When severe G6PD deficiency complicates malariainfection, treatment with primaquine or dapsone can lead tolife-threatening acute intravascular hemolysis followed by anemiaand acute renal failure
944.Glucagon and epinephrine are similar in that both promoteglycogenolysis.- true
Explanation- Glycogenolysisis the breakdown of the moleculeglycogen into glucose. Glucagon and epinephrine trigger thebreakdown of glycogen. Epinephrine stimulates glycogen breakdown inmuscle and, to a lesser extent, in the liver. The liver is moreresponsive to glucagon, a polypeptide hormone that is secreted bythe α cells of the pancreas when the blood-sugar level is low.
943.Phosphofructokinase activity can be decreased by AMP.-false
Explanation- . PFK catalyzes the conversion offructose-6-phosphate to fructose-1,6-bisphosphate in glycolysis.PFK is inhibited by ATP and citrate and positivelyregulated by AMP.
942.Protein phosphatase can reverse the action of the kinase onenzymes.- true
Explanation- Protein serine/threonine phosphatases are enzymesthat reverse the actions of protein kinases by cleaving phosphatefrom serine and threonine residues in proteins.
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